The sprawling, 6,420-square-foot space at 6 E. 2nd St. is where the Ramones played their first show in 1975. It was often used as a crash pad for lead singer Joey and bassist Dee Dee.

The property is also where Arturo Vega, who worked as the the beloved punk rock band’s creative director, lighting director and historian, lived from the 1970s until his death in 2013.

Vega, whom Dee Dee once called the band’s “evil mom” was also known as the “fifth Ramone.” He created the Ramones’ eagle logo and attended all but two of their 2,263 shows between 1974 and 1996.

The building where the iconic loft is located — near the intersection of Bowery and East Second Street, which was renamed Joey Ramone Place and is now the most stolen street sign in the city — is now on the market for $7.25 million.

It features three full-floor lofts and a ground-floor commercial space, currently occupied by the John Derian Company, a home decor brand.

The listing brokers are Paul J. Massey, Jr., Zach Redding and Daniel O’Mahony, of B6 Real Estate Advisors.